| SKU:K1307 | M. Wt:424.43 | ||
| Formula:C19H16N6O4S | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:186497-07-4 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1307 |
| CAS号： | 186497-07-4 |
| SKU:K1307 | M. Wt:424.43 | ||
| Formula:C19H16N6O4S | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:186497-07-4 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | Zibotentan (ZD4054) | |||||
|---|---|---|---|---|---|---|
| Targets | Endothelin A (ETA) | |||||
| IC50 | 21 nM | |||||
| In vitro | As a specific Endothelin A, zibotentan can binds to endothelin A receptor (ETA) with Ki of 13 nM.But zibotentan do not shows inihbition to endothelin B receptor (ETB). Zibotentan can block ET-1 induced EGFR transactivation and mitogenic activity in ovarian carcinoma cell lines HEY and OVCA 433 at the concentration of 1 uM. | |||||
| In vivo | Administration of Zibotentan(10 mg/kg/day)can potently inhibits the growth of HEY ovarian carcinoma xenografts in mice by 69%. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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