SKU:K1308 | M. Wt:440.58 | ||
Formula:C27H32N6 | Solubility:No | ||
Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
CAS No.:497839-62-0 | Synonyms:N/A | ||
Chemical NameN/A |
供货周期: | 7天 |
品牌: | |
型号: | 2mg |
货号: | K1308 |
CAS号: | 497839-62-0 |
SKU:K1308 | M. Wt:440.58 | ||
Formula:C27H32N6 | Solubility:No | ||
Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
CAS No.:497839-62-0 | Synonyms:N/A | ||
Chemical NameN/A |
Description | AEE788 (NVP-AEE788) | |||||
---|---|---|---|---|---|---|
Targets | EGFR | ErbB2 | KDR | Flt-1 | ||
IC50 | 2 nM | 6 nM | 77 nM | 59 nM | ||
In vitro | AEE788 can potently inhibit EGFR, ErbB2, KDR, and Flt-1with IC50 of 2 nM, 6 nM, 77 nM and 59 nM, respectively. | |||||
In vivo | AEE788 inhibits EGFR and ErbB2 phosphorylation in cells with IC50 of 11 nM and 22 nM, respectively. AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines (including EGFRvIII-dependent lines) and inhibited the proliferation of epidermal growth factor- and VEGF-stimulated human umbilical vein endothelial cells. AEE788 shows potent antitumor activity in a number of animal models of cancer, including tumors that overexpress EGFR and or ErbB2. AEE788 was able to inhibit the proliferation and induce apoptosis of ATC cell lines in vitro, and anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies.[2]Treatment of cutaneous SCC cells with AEE788 led to dose-dependent inhibition of EGFR and VEGFR-2 phosphorylation, growth inhibition, and induction of apoptosis.[3] | |||||
Clinical Trials | N/A | |||||
Features | N/A |
重组人肌球蛋白轻链2(Recombinant Human MYL2)
重组大鼠抵抗素(Rat Resistin)
大鼠酸性磷酸酶(ACP)ELISA Kit
大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit
人瘦素(LEP)ELISA Kit
重组人半乳糖凝集素16/LGALS16 Human
重组人半乳糖凝集素8/Human LGALS8 His
重组人半乳糖凝集素3/Human LGALS3 His
重组人卵泡抑素/Human FST His
重组人β防御素118/DEFB118 Human
重组人心肌营养素1/CTF1 Human
特级新生牛血清(无支原体)
超级新生牛血清(无支原体)
优级胎牛血清(无支原体)
特级新生牛血清(无噬菌体低内毒素)
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