| SKU:K1310 | M. Wt:512.5 | ||
| Formula:C26H24F4N6O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1258861-20-9, | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1310 |
| CAS号： | 1258861-20-9 |
| SKU:K1310 | M. Wt:512.5 | ||
| Formula:C26H24F4N6O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1258861-20-9, | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | LY2940680 | |||||
|---|---|---|---|---|---|---|
| Targets | ||||||
| IC50 | N/A | |||||
| In vitro | LY2940680 can inhibit Hh signaling in uman medulloblastoma tumor cell lines and mouse mesenchymal cell lines.LY2940680 treatment induced Caspase-3 activity and reduced proliferation. LY2940680 binds to and inhibits the functional activity of resistant Smo mutant (D473H) produced by treatment with GDC-0449. | |||||
| In vivo | LY2940680 inhibited Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produced significant anti-tumor activity. In Ptch+/ÿ p53ÿ/ÿ transgenic mice, oral administration of LY2940680 shows remarkable efficacy and significantly improve their survival. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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