Indirubin|5mg|K1312-上海高创化学科技有限公司

Indirubin

参考价：¥836

供货周期：

一周

品牌：

规格：

5mg

货号：

K1312

CAS号：

479-41-4

SKU:K1312		M. Wt:262.26
Formula:C16H10N2O2		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:479-41-4		Synonyms:N/A
Chemical NameN/A

Description	Indirubin
Targets	CDK	GSK-3beta
IC50	75 nM	190 nM
In vitro	Indirubin, a bis-indole obtained from various natural sources, is responsible for the reported antileukemia activity of a Chinese Medicinal recipe, Danggui Longhui Wan.A dramatic cytostatic effect, as measured by actual cell counts and associated with a sharp G1 phase arrest, is induced by 1-methyl-indirubins, a subfamily of AhR-active but kinase-inactive indirubins.In the time-course experiment, CYP1A1 mRNA is induced by indirubin transiently. Indirubin was also metabolized by CYP1A1 and lost its ligand activity. Indirubin would appear to be a good substrate of CYP1A1 given its low dissociation constant.Levels of cytochrome P450 1A1/2 proteins and mRNAs in the liver of mice dosed with indirubin were also enhanced.
In vivo	When indirubin and indigo were administered to mice, ethoxyresorufin-O-dealkylase and methoxyresorufin-O-dealkylase activities in the liver were increased, but subsequently decreased within 2 days.
Clinical Trials	N/A
Features	N/A

Description

Indirubin

Targets

CDK

GSK-3beta

IC50

75 nM

190 nM

In vitro

Indirubin, a bis-indole obtained from various natural sources, is responsible for the reported antileukemia activity of a Chinese Medicinal recipe, Danggui Longhui Wan.A dramatic cytostatic effect, as measured by actual cell counts and associated with a sharp G1 phase arrest, is induced by 1-methyl-indirubins, a subfamily of AhR-active but kinase-inactive indirubins.In the time-course experiment, CYP1A1 mRNA is induced by indirubin transiently. Indirubin was also metabolized by CYP1A1 and lost its ligand activity. Indirubin would appear to be a good substrate of CYP1A1 given its low dissociation constant.Levels of cytochrome P450 1A1/2 proteins and mRNAs in the liver of mice dosed with indirubin were also enhanced.

In vivo

When indirubin and indigo were administered to mice, ethoxyresorufin-O-dealkylase and methoxyresorufin-O-dealkylase activities in the liver were increased, but subsequently decreased within 2 days.

Clinical Trials

N/A

Features

N/A