Isoliquiritigenin

Isoliquiritigenin

参考价：¥836
供货周期： 一周
品牌：
规格： 2mg
货号： K1313
CAS号： 961-29-5
上海高创化学科技有限公司
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SKU:K1313   M. Wt:256.25  
Formula:C15H12O4   Solubility:N/A  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:961-29-5   Synonyms:N/A  
Chemical NameN/A
Biological Activity
Description Isoliquiritigenin (ISL) is a chalcone compound with valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer and anti-allergic activities.Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABA receptors and shows hypnotic effects.
Targets          
IC50 N/A        
In vitro Isoliquiritigenin (ISL) is a chalcone compound with valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer and anti-allergic activities.Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABA A receptors and shows hypnotic effects. ISL also can suppress HIF-1alpha level, VEGF expression and secretion, cell migration and to decrease the expression and secretion of MMP-9/-2. ISL inhibited the proliferation of U87 cells in a time-dependent and dose-dependent manner.ISL induced the apoptosis of the U87 cells and blocked cell cycle progression at the S and G2/M phases. ISL induced the apoptosis of the U87 cells in a caspase-dependent manner. ISL upregulated p21/WAF1 and p27. Cell cycle arrest and the caspase-mediated apoptosis pathway may participate in the antiproliferative activity of ISL in U87 cells by regulating the expression of ISL. There is a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis. Isoliquiritigenin also can inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT). 100uM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%. Low concentration of ISL may have therapeutic potential in the treatment of aggressive breast carcinoma and other neoplasms.
In vivo The tumorigenicity of ISL-treated cells was limited significantly in an animal model assay in vivo respectively.
Clinical Trials N/A
Features N/A

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