| SKU:K1314 | M. Wt:464.48 | ||
| Formula:C23H27F3N4O3 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:908112-43-6, 945626-71-1 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1314 |
| CAS号： | 908112-43-6 |
| SKU:K1314 | M. Wt:464.48 | ||
| Formula:C23H27F3N4O3 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:908112-43-6, 945626-71-1 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | SNX-2112 | |||||
|---|---|---|---|---|---|---|
| Targets | HSP90-alpha | HSP90-beta | ||||
| IC50 | 30 nM(Ka) | 30 nM(Ka) | ||||
| In vitro | As a selective and ATP-compeitive inhibitor, SNX-2112 can inhibit HSP90alpha and HSP90beta with Ka of 30 nM and 30 nM by competitively binding to the N-terminal adenosine triphosphate binding site of Hsp90. SNX-2112 inhibits cell proliferatin of BT474, SKBR-3, SKOV-3, MDA-468, MCF-7 and H1650 cancer cells with IC50 from 10 to 50 nM.SNX-2112 also can induces cell apoptosis by inducing caspase-8, -9, -3, and poly (ADPribose) polymerase cleavage. ERK and Akt can be activated by SNX-2112. By abrogating eNOS/Akt pathway, SNX-2112 inhibits tube formation in human umbilical vein endothelial cells. | |||||
| In vivo | In a xenograft murine model, SNX-2112 can inhibits MM cell growth and prolongs survival. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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