AG-1024 (Tyrphostin)

AG-1024 (Tyrphostin)

报价:¥836
供货周期: 7天
品牌:
型号: 2mg
货号: K1321
CAS号: 65678-07-1
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SKU:K1321   M. Wt:305.17  
Formula:C14H13BrN2O   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:65678-07-1   Synonyms:N/A  
Chemical NameN/A
Biological Activity
Description AG-1024 (Tyrphostin)
Targets IGF-1R        
IC50 400 nM        
In vitro Tyrphostin AG1024 can inhibit IGF-1R with IC50 of around 400 nM. By inhibiting insulin-like growth factor 1 receptor and insulin receptor, Tyrphostin AG1024 arrested melanoma cell growth. Tyrphostin AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function.
In vivo Administration of AG-1024 at a dose of 30 ug for 10 days significantly inhibits the tumor growth of Ba/F3-p210 xenograft in mice.
Clinical Trials N/A
Features N/A

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