| SKU:K1322 | M. Wt:383.4 | ||
| Formula:C22H17N5O2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1002304-34-8 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1322 |
| CAS号： | 1002304-34-8 |
| SKU:K1322 | M. Wt:383.4 | ||
| Formula:C22H17N5O2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1002304-34-8 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | AMG-208 | |||||
|---|---|---|---|---|---|---|
| Targets | c-Met | |||||
| IC50 | 9.3 nM | |||||
| In vitro | As a selective inhibitor, AMG-208 can potently inhibit c-Met with IC50 of 9.3 nM. In PC3 cells, AMG-208 also can induce inhibition to c-Met phosphorylation mediated by HGF with IC50 of 46 nM. | |||||
| In vivo | AMG-208 exhibits favorable pharmacokinetics and displayed potent inhibition of HGF-mediated c-Met phosphorylation in a mouse liver PD model. Once-daily oral administration of 24 for 22days showed significant tumor growth inhibition in an NIH-3T3/TPR-Met xenograft mouse efficacy model. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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