Mubritinib(TAK 165)

Mubritinib(TAK 165)

报价:¥793
供货周期: 7天
品牌:
型号: 10mg
货号: K1324
CAS号: 366017-09-6
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Information
SKU:K1324   M. Wt:468.47  
Formula:C25H23F3N4O2   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:366017-09-6   Synonyms:TAK 165, TAK165  
Chemical NameN/A
Biological Activity
Description Mubritinib(TAK 165)
Targets ErbB2        
IC50 6 nM        
In vitro TAK-165 can inhibit HT1376, UMUC3, T24 (bladder), ACHN (kidney), DU145, LNCaP, LN-REC4 (prostate) cell lines, which are observed HER2 expression, with IC50 from 0.09 to greater than 25 micromol/L. The prostate cancer cell lines are all sensitive to mubritinib (TAK 165).Mubritinib (TAK 165) can inhibit prostate cancer cell lines with IC50 from 0.053to 4.62 micromol/L.
In vivo In the xenograft model, treatment with TAK-165 significantly inhibited growth of UMUC-3, ACHN, and LN-REC4. The antitumor effect (T/C [%]=growth of TAK-165 treated tumor/average growth of control tumorx100) after 14 days treatment were 22.9%, 26.0%, and 26.5% in UMUC3, ACHN and LN-REC4, respectively.
Clinical Trials N/A
Features N/A

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