AZ 3146

AZ 3146

参考价：¥1056
供货周期： 一周
品牌：
规格： 5mg
货号： K1330
CAS号： 1124329-14-1
上海高创化学科技有限公司
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SKU:K1330   M. Wt:452.55  
Formula:C24H32N6O3   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:1124329-14-1   Synonyms:N/A  
Chemical NameN/A
Biological Activity
Description AZ 3146
Targets MSP1        
IC50 35 nM        
In vitro AZ3146 inhibits human Mps1Cat with an IC50 of 35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells. AZ3146 is a reasonably potent and selective Mps1 inhibitor. AZ3146 overrides the spindle checkpoint. HeLa cells treated with nocodazole and 2 ?M AZ3146 only delayed mitosis briefly and then rereplicated their genomes. During an otherwise unperturbed mitosis, AZ3146 reduced the time to complete mitosis from 90 min in controls to 32 min. During mitosis, Mps1 activity is required continuously to recruit Mad2 to kinetochore-bound Mad1, but AZ3146 can abolish Mad2 localization. And inhibition of Mps1 by AZ3146 can increase its abundance at kinetochores.
In vivo  
Clinical Trials N/A
Features N/A

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