| SKU:K1345 | M. Wt:501.62 | ||
| Formula:C28H35N7O2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:398493-79-3 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 7天 |
| 品牌： | |
| 型号： | 2mg |
| 货号： | K1345 |
| CAS号： | 398493-79-3 |
| SKU:K1345 | M. Wt:501.62 | ||
| Formula:C28H35N7O2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:398493-79-3 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | PHA-680632 | |||||
|---|---|---|---|---|---|---|
| Targets | Aurora A | Aurora B | Aurora C | |||
| IC50 | 27 nM | 135 nM | 120 nM | |||
| In vitro | PHA-680632 potently inhibits all three Aurora kinases (A, B, and C) with IC50 values of 27, 135, and 120 nM, respectively. PHA-680632 (0.5 uM) causes polyploidy in tumor cells. The mechanism of action of PHA-680632 is in agreement with inhibition of Aurora kinases. [1] PHA680632 in association with radiation leads to additive effects in cancer cells, especially in the p53-deficient cells. | |||||
| In vivo | PHA-680632 (45 mg/kg) suppresses growth of activated ras-driven mammary tumors in mouse mammary tumor virus v-Ha-ras transgenic mice and results in complete tumor stabilization and partial regression. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
重组人肌球蛋白轻链2(Recombinant Human MYL2)
重组大鼠抵抗素(Rat Resistin)
大鼠酸性磷酸酶(ACP)ELISA Kit
大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit
人瘦素(LEP)ELISA Kit
重组人半乳糖凝集素16/LGALS16 Human
重组人半乳糖凝集素8/Human LGALS8 His
重组人半乳糖凝集素3/Human LGALS3 His
重组人卵泡抑素/Human FST His
重组人β防御素118/DEFB118 Human
重组人心肌营养素1/CTF1 Human
特级新生牛血清（无支原体）
超级新生牛血清（无支原体）
优级胎牛血清（无支原体）
特级新生牛血清（无噬菌体低内毒素）
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