| SKU:K1346 | M. Wt:594.05 | ||
| Formula:C31H29F2N5O3.HCl | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:957116-20-0 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1346 |
| CAS号： | 957116-20-0 |
| SKU:K1346 | M. Wt:594.05 | ||
| Formula:C31H29F2N5O3.HCl | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:957116-20-0 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | MK 3207 HCl | |||||
|---|---|---|---|---|---|---|
| Targets | CGRP | |||||
| IC50 | 0.12 nM | |||||
| In vitro | Although has affinity for AMY1 (CTR/RAMP1) receptor with a Ki value of 0.75 nM, MK 3207 displays marked selectivity for human CGRP receptor versus related human AM1 (CLR/RAMP2) receptor, AM2 (CLR/RAMP3) receptor, AMY3 (CTR/RAMP3) receptor, and CTR with Ki values of 16.5 uM, 0.156 uM, 0.128 uM and 1.9 uM, respectively. | |||||
| In vivo | Administration of MK 3207 produces a concentration-dependent inhibition of capsaicin-induced dermal vasodilation in rhesus monkeys, blocking the blood flow increase with an EC50 of 0.8 nM and an EC90 of 7 nM, respectively. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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