| SKU:K1356 | M. Wt:320.39 | ||
| Formula:C19H20N4O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1038915-60-4 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1356 |
| CAS号： | 1038915-60-4 |
| SKU:K1356 | M. Wt:320.39 | ||
| Formula:C19H20N4O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:1038915-60-4 | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | MK-4827 | |||||
|---|---|---|---|---|---|---|
| Targets | PARP1 | PARP2 | ||||
| IC50 | 3.8 nM | 2.1 nM | ||||
| In vitro | MK-4827 can inhibit PARP1 and PARP2 with IC50 of 3.8 nM and 2.1 nM. MK-4827 can inhibit PARP activity with EC50 of 4 nM. | |||||
| In vivo | MK-4827 strongly enhances the effect of radiation on a variety of human tumor xenografts, both p53 wild type and p53 mutant. The enhancement of radiation response is observed in clinically relevant radiation-dose fractionation schedules. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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