| SKU:K1358 | M. Wt:136.15 | ||
| Formula:C7H8N2O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:3544-24-9, 220583-51-7 (TFA) | Synonyms:N/A | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1358 |
| CAS号： | 3544-24-9 |
| SKU:K1358 | M. Wt:136.15 | ||
| Formula:C7H8N2O | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:3544-24-9, 220583-51-7 (TFA) | Synonyms:N/A | ||
| Chemical NameN/A | |||
| Description | INO-1001 | |||||
|---|---|---|---|---|---|---|
| Targets | PARP | |||||
| IC50 | 50 nM | |||||
| In vitro | INO-1001 can potently inhibits PARP with IC50 of 50 nM.. Inhibition of PARP activity by INO-1001 significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 uM H2O2. | |||||
| In vivo | In a db/db (Leprdb/db) mouse model, INO-1001 ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
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