| SKU:K1360 | M. Wt:259.34 | ||
| Formula:C16H21NO2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:196597-26-9 | Synonyms:Rozerem, TAK-375 | ||
| Chemical NameN/A | |||
| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1360 |
| CAS号： | 196597-26-9 |
| SKU:K1360 | M. Wt:259.34 | ||
| Formula:C16H21NO2 | Solubility:No | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:196597-26-9 | Synonyms:Rozerem, TAK-375 | ||
| Chemical NameN/A | |||
| Description | Ramelteon(TAK-375) | |||||
|---|---|---|---|---|---|---|
| Targets | MT1 receptor | MT2 receptor | MT receptor (chicken) | |||
| IC50 | 14 pM (Ki) | 112 pM (Ki) | 23.1 pM (Ki) | |||
| In vitro | Ramelteon (TAK-375) can inhibit MT1 receptor and MT2 receptor with Ki of 14 pM and 112 pM. Ramelteon has high affinity with recombinant human MT1 and MT2 receptors with pKi of 10.05 and 9.70. Ramelteon (1 nM) increases ERK1/2 phosphorylation not only in MT1/MT2 cerebellar granule cells but also in cerebellar granule cells expressing only one of the two melatonin receptors. | |||||
| In vivo | Ramelteon (10 mg/kg, i/p) significantly reduces NREM sleep latency in rat and also produces a short-lasting increase in nonrapid eye movement (NREM) sleep duration, but the NREM power spectrum is unaltered. | |||||
| Clinical Trials | N/A | |||||
| Features | N/A | |||||
相关产品
重组人肌球蛋白轻链2(Recombinant Human MYL2)
重组大鼠抵抗素(Rat Resistin)
大鼠酸性磷酸酶(ACP)ELISA Kit
大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit
人瘦素(LEP)ELISA Kit
重组人半乳糖凝集素16/LGALS16 Human
重组人半乳糖凝集素8/Human LGALS8 His
重组人半乳糖凝集素3/Human LGALS3 His
重组人卵泡抑素/Human FST His
重组人β防御素118/DEFB118 Human
重组人心肌营养素1/CTF1 Human
特级新生牛血清（无支原体）
超级新生牛血清（无支原体）
优级胎牛血清（无支原体）
特级新生牛血清（无噬菌体低内毒素）
工商信息
信息已认证
联系方式
详细地址
关注
拨打电话
留言咨询
