Vicriviroc Malate

Vicriviroc Malate

参考价：¥1518
供货周期： 一周
品牌：
规格： 2mg
货号： K1364
CAS号： 541503-81-5
上海高创化学科技有限公司
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SKU:K1364   M. Wt:667.72  
Formula:C28H38F3N5O2.C4H6O5   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:541503-81-5, 541503-48-4 (HCl), 306296-47-9 (free base)   Synonyms:N/A  
Chemical NameN/A
Biological Activity
Description Vicriviroc Malate
Targets CCR5        
IC50 0.91 nM        
In vitro Vicriviroc is nearly 6-fold less active than SCH-C (IC50 = 5.8 uM versus 1.1 uM) in attenuating hERG current among voltage-clamped L929 cells, indicating a reduced potential for cardiac effects. Vicriviroc inhibits MIP-1alpha induced migration of Ba/F3 cells stably expressing recombinant human CCR5, with IC50 of 0.91 nM. Vicriviroc is also highly active against a Clade G Russian isolate RU570 with EC90 of 16 nM, which is resistant to inhibition by SCH-C (EC90 > 1 uM). Vicriviroc could target an early step in the viral life cycle prior to reverse transcription and virion maturation, the targets of reverse transcriptase inhibitor and protease inhibitor, respectively.
In vivo N/A
Clinical Trials N/A
Features N/A

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