GSK1070916

GSK1070916

参考价：¥1518
供货周期： 一周
品牌：
规格： 2mg
货号： K1370
CAS号： 942918-07-2
上海高创化学科技有限公司
银牌会员 丨 7年 丨 生产商
关注展位 全部试剂
产品详情

Information
SKU:K1370   M. Wt:507.63  
Formula:C30H33N7O   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:942918-07-2   Synonyms:N/A  
Chemical NameN/A
Biological Activity
Description GSK1070916
Targets Aurora B Aurora C      
IC50 3.5 nM 6.5 nM      
In vitro GSK1070916 can inhibit Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM. Human tumor cells treated with GSK1070916 shows dose-dependent inhibition of phosphorylation on serine 10 of Histone H3, a substrate specific for Aurora B. Moreover, GSK1070916 inhibits the proliferation of tumor cells with EC50 values of <10 nM in over 100 cell lines spanning a broad range of tumor types, with a median EC50 of 8 nM.
In vivo GSK1070916 (25, 50, or 100 mg/kg) shows dose-dependent inhibition of phosphorylation of an Aurora B specific substrate in mice and consistent with its broad cellular activity, has antitumor effects in 10 human tumor xenograft models including breast, colon, lung, and two leukemia models. [2]
Clinical Trials N/A
Features N/A

相关产品

同类推荐 更多
GSK1070916由上海高创化学科技有限公司为您提供，货号K1370，规格：2mg，CAS号：942918-07-2，如您想了解更多关于GSK1070916价格、GSK1070916结构式、批发、用途等信息，欢迎咨询。除供应GSK1070916外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。
Business information
工商信息 信息已认证
contact us
联系方式

详细地址

上海市涞亭南路888弄238号
当前位置： 上海高创 试剂 GSK1070916

关注

拨打电话

留言咨询