Loratadine|10mg|K1378-上海高创化学科技有限公司

Loratadine

参考价：¥836

供货周期：

一周

品牌：

规格：

10mg

货号：

K1378

CAS号：

79794-75-5

SKU:K1378		M. Wt:382.88
Formula:C22H23ClN2O2		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:79794-75-5		Synonyms:Alavert, Claritin
Chemical NameN/A

Description	Loratadine
Targets	N/A
IC50	N/A
In vitro	Loratadine(SCH 29851) is discovered as part of a search for a new antihistamine without effects on the central nervous system (CHS). SCH 29851 has antihistamine activity in the tests used with a potency at least comparable to most standards.[1]
In vivo	Loratadine exhibits a more pronounced inhibition of histamine wheal formation than placebo or chlorpheniramine maleate (p less than 0.003). Loratadine inhibited the response for the entire observation period between 1 and 24 h post-dose. [2]SCH 29851 at 80 mg/kg po in mice, a dose about 50 times its ED50 for blocking histamine-induced paw edema in the same species, potentiated the anticonvulsant effects of diazepam. At the high dose of 320 mg/kg po, about 80 times its ED50 for antihistamine effects, SCH 29851 potentiated the ability of high doses of ethanol and hexobarbital to induce loss of righting reflexes (LRR).[3]
Clinical Trials	N/A
Features	N/A

Description

Loratadine

Targets

N/A

IC50

N/A

In vitro

Loratadine(SCH 29851) is discovered as part of a search for a new antihistamine without effects on the central nervous system (CHS). SCH 29851 has antihistamine activity in the tests used with a potency at least comparable to most standards.[1]

In vivo

Loratadine exhibits a more pronounced inhibition of histamine wheal formation than placebo or chlorpheniramine maleate (p less than 0.003). Loratadine inhibited the response for the entire observation period between 1 and 24 h post-dose. [2]SCH 29851 at 80 mg/kg po in mice, a dose about 50 times its ED50 for blocking histamine-induced paw edema in the same species, potentiated the anticonvulsant effects of diazepam. At the high dose of 320 mg/kg po, about 80 times its ED50 for antihistamine effects, SCH 29851 potentiated the ability of high doses of ethanol and hexobarbital to induce loss of righting reflexes (LRR).[3]

Clinical Trials

N/A

Features

N/A