Febuxostat (Uloric)

Febuxostat (Uloric)

参考价：¥836
供货周期： 一周
品牌：
规格： 5mg
货号： K1381
CAS号： 144060-53-7
上海高创化学科技有限公司
银牌会员 丨 7年 丨 生产商
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SKU:K1381   M. Wt:316.37  
Formula:C16H16N2O3S   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:144060-53-7   Synonyms:Adenuric  
Chemical NameN/A
Biological Activity
Description Febuxostat (Uloric)
Targets XO        
IC50 0.6 nM        
In vitro Febuxostat displays potent mixed-type inhibition of the activity of purified bovine milk XO, with Ki and Ki' values of 0.6 and 3.1 nM respectively. Febuxostat(TMX-67), a newly synthesized xanthine oxidase/xanthine dehydrogenase (XOD/XDH) inhibitor, has almost no effect on DNFB-sensitized mice.[1] At concentrations up to 100 muM, febuxostat has no significant effects on the activities of the following enzymes of purine and pyrimidine metabolism: guanine deaminase, hypoxanthine-guanine phosphoribosyltransferase, purine nucleoside phosphorylase, orotate phosphoribosyltransferase and orotidine-5'-monophosphate decarboxylase.[2]
In vivo Febuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily dose of 300 mg in lowering serum urate.[3] Daily febuxostat doses in the range 10 mg to 120 mg resulted in proportional mean serum urate reductions ranging from 25% to 70% and in proportional increases in maximum febuxostat plasma concentrations and area under plasma concentration versus time curves.[4]
Clinical Trials N/A
Features N/A

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