Silodosin (Rapaflo)

Silodosin (Rapaflo)

参考价：¥1298
供货周期： 一周
品牌：
规格： 2mg
货号： K1384
CAS号： 160970-54-7
上海高创化学科技有限公司
银牌会员 丨 7年 丨 生产商
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SKU:K1384   M. Wt:495.53  
Formula:C25H32F3N3O4   Solubility:No  
Purity:>99%   Storage:2 years at -20 degrees centigrade  
CAS No.:160970-54-7   Synonyms:KAD 3213, KMD 3213  
Chemical NameN/A
Biological Activity
Description Silodosin (Rapaflo)
Targets alpha(1)-adrenoceptor        
IC50 N/A        
In vitro KMD 3213(silodosin, KAD 3213) is an orally active alpha(1)-adrenoceptor antagonist.[1] Silodosin shows higher selectivity for the alpha(1A)-AR subtype than tamsulosin hydrochloride, naftopidil or prazosin hydrochloride.Silodosin strongly antagonizes noradrenaline-induced contractions in rabbit lower urinary tract tissues.[2] silodosin inhibits the phenylephrine-induced increase in intraurethral pressure for a longer time than tamsulosin hydrochloride.[3]
In vivo Silodosin is a dual substrate for CYP3A4 and p-glycoprotein. After a single oral dose of (14)C-silodosin in rat, dog and human, the urinary excretion of radioactivity was 15-34%, with that of unchanged silodosin being less than 4%.[4]Intravenously (i.v.) administered silodosin dose-dependently inhibited the HNS-induced increase in IUP with much less hypotensive effect than either tamsulosin or naftopidil, the uroselectivity (ED(15)/ID(50)) of silodosin (237) being significantly higher than those of tamsulosin (1.21) and naftopidil (2.65).[5]
Clinical Trials N/A
Features N/A

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