| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1387 |
| CAS号： | 582315-72-8 |
| SKU:K1387 | M. Wt:345.34 | ||
| Formula:C18H17F2N3O2 | Solubility:DMSO 20 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL | ||
| Purity:>99% | Storage:2 years at -20°C Powder | ||
| CAS No.:582315-72-8 | Synonyms:N/A | ||
| Chemical Name (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2, 6-difluoro-4-methylphenyl)methanone | |||
| Description | BMS-265246 | |||||
|---|---|---|---|---|---|---|
| Targets | CDK1/cyclin B | CDK2/cyclin E | ||||
| IC50 | 6 nM | 9 nM | ||||
| In vitro | BMS265246 can potently inhibit CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively. | |||||
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