| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 5mg |
| 货号： | K1388 |
| CAS号： | 694433-59-5 |
| SKU:K1388 | M. Wt:335.4 | ||
| Formula:C20H21N3O2 | Solubility:DMSO 67 mg/mL,Water <1 mg/mL, Ethanol 67 mg/mL | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:694433-59-5 | Synonyms:N/A | ||
| Chemical Name2-[4-(1, 3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine | |||
| Description | SB-505124 | |||||
|---|---|---|---|---|---|---|
| Targets | ||||||
| IC50 | ||||||
| In vitro | SB505124 shows no toxicity to renal epithelial A498 cells at concentrations up to 100 uM for 48 hours, and blocks TGF-beta-induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. [1] In human umbilical vein endothelial cells (HUVEC), SB505124 (500 nM) blocks the changes of TGF-beta1 on F-actin assembly and prevents ROS production induced by TGF-beta. | |||||
| In vivo | In a rabbit GFS model, SB505124 decreased the intraocular pressure (IOP) levels and reduces subconjunctival cell infiltration and scarring at the surgical site in the GFS. | |||||
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