Eltrombopag (SB-497115-GR)

Eltrombopag (SB-497115-GR)

参考价:¥1361
供货周期: 一周
品牌:
规格: 5mg
货号: K1389
CAS号: 496775-61-2
上海高创化学科技有限公司
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Information
SKU:K1389   M. Wt:442.47  
Formula:C25H22N4O4   Solubility:N/A  
Purity:>99%   Storage:2 years at -20°C Powder  
CAS No.:496775-61-2   Synonyms:SB-497115-GR, Revolade, Promacta  
Chemical Name3-[(5E)-5-[[2-(3, 4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6- oxocyclohexa-1,3-dien-1-yl]benzoic acid
Biological Activity
Description Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 uM for the inhibition of hERG K+ channel tail current. In preclinical studies, the compound was shown to interact selectively with the thrombopoeitin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes. Animal studies confirmed that administration could increase platelet counts.

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