| 供货周期： | 一周 |
| 品牌： | |
| 规格： | 2mg |
| 货号： | K1412 |
| CAS号： | 850876-88-9 |
| SKU:K1412 | M. Wt:731.83 | ||
| Formula:C35H46FN5O9S | Solubility:DMSO 144 mg/mL, Water <1 mg/mL, Ethanol 144 mg/mL | ||
| Purity:>99% | Storage:2 years at -20°C Powder | ||
| CAS No.:850876-88-9 | Synonyms:RG7227, ITMN-191, RO5190591 | ||
| Chemical Name2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a] | |||
| Description | Danoprevir (0.29 nM) inhibits the reference genotype 1 NS3/4A protease half-maximally. | |||||
|---|---|---|---|---|---|---|
| Targets | ||||||
| IC50 | ||||||
| In vitro | Danoprevir (0.29 nM) inhibits the reference genotype 1 NS3/4A protease half-maximally, but a high dose of Danoprevir (10 μM) shows no appreciably inhibition in a panel of 79 proteases, ion channels, transporters, and cell surface receptors. Danoprevir remains bound to and inhibits NS3/4A for more than 5 hours after its initial association. Danoprevir (45 nM) eliminates a patient-derived HCV genotype 1b replicon from hepatocyte-derived Huh7 cells with an EC50 of 1.8 nM. | |||||
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