型号: | CellKey 384 |
产地: | 美国 |
品牌: | 美谷分子 |
评分: |
|
Feature | Benefit |
Sensitive to endogenous receptors | Enables reliable and robust measurements of endogenous cellular receptor activity, even low density receptors which may be undetectable with other functional assays. |
Label free detection | Expensive tags, dyes, or specialized reagents are not required. This reduces the resources required for assay development and eliminates the incidence of undesirable interactions with labels. |
Universal platform for functional cell surface target assays | Single platform and assay methodology measures GPCRs, TKRs, adhesion molecules, and indirectly measures ligand-gated ion channels, among other targets. |
Measures all cell types | System measures disease and biologically relevant cell lines and primary cells, including adherent and non-adherent cell types. |
Measures all classes of compound efficacy | Comprehensive detection of agonists, antagonists, partial and inverse agonists, and allosteric modulators in a native setting in a single assay. |
Information-rich kinetic response data |
Reproducible and robust qualitative pathway-specific cell response profiles. Probe complex receptor signaling, pathway diversity, and identify the underlying mechanism of action (MOA) of lead compounds. |
Streamlined assay development |
Single-assay format for multiple receptor types regardless of signal coupling mechanism. Reduces the resources spent on assay development, such as time consuming and costly biological manipulation of cell lines and the optimization of labeling reagents. |
384-well format | 384-well measurement and fluidics accelerates throughput for label-free cell-based kinetic screening, up to 25000 wells in an 8 hour period. Reduces per well cost, due to high density format and decreases cells/well and reagent needs. |
Integrated, internal pipettor head | Simultaneous addition of ligand and/or compound while measuring the fast kinetic cellular responses, delivers reproducible and robust response profiles, with no loss of information. |
On-board tip wash system | Online tip washing extends unattended operation during extended runs, increases throughput capability, and reduces running costs. |
Automation-friendly | Designed for easy robotic integration with small and large scale automation platforms. |
Ease of use | The CellKey 384 System is a fully integrated, flexible, and intuitive platform. |
Measurements | |
Assay type: | Homogeneous, label-free, cell-based |
Principles: | Impedance |
Frequency range: | 1 kHz-10 MHz |
Mode: | Kinetic measurement: simultaneous compound addition and measurement across all wells |
Data acquisition rate: | 4 or 20 second update rate |
Microplate Formats | |
Cell plate format: | 384-well proprietary cell plate |
Compound plate format: | 384-well compound plates and reservoirs |
Deck positions: |
One read (cell plate) position Two compound plate positions One tip loading position |
Fluidics | |
Pipettor format: | One 384 well pipettor head, simultaneous transfer |
Pipettor range: | 0.5-25 μL |
Pipetting increments: | 0.1 μL |
Dispense speed: | Adjustable |
Pipettor height: | Adjustable |
Additional standard features: |
Compound mix capability Tip wash capability |
Throughput | |
Assay development: | 4 plates/hour (15-minute read time) |
High-throughput: | 8 plates/hour or better (5-minute read time, plus automation) |
Temperature Range | |
Analysis range: | Ambient +5° to 37°C (below 20°C, ambient +6°) |
Ambient range: | 15-30oC |
Physical Characteristics | |
Benchtop | Yes |
Instrument weight: | 145 kg/320 lbs |
Instrument dimensions (in): | 28 (H) x 39 (W) x 23 (D) |
Instrument dimensions (cm): | 70 (H) x 100 (W) x 58 (D) |
Tip wash control unit weight: | 16 kg/35 lbs |
Tip wash control unit dimensions (in): | 19 (H) x 8 (W) x 12 (D) |
Tip wash control unit dimensions (mm): | 480 (H) x 210 (W) x 315 (D) |
Power consumption: | 700 W |
Power source: |
100-120/200-240 V (self-adjusting) 50/60 Hz |
Computer | |
Processor: | Minimum: Intel® CoreTM2 Dual Core 2.66 GHz processor, 2 GB RAM |
LCD monitor: | 20-inch |
Operating system: | Windows® XP |
Regulatory | |
Regulatory: | For Research Use Only. Not for Use in diagnostic procedures |
相关产品
SpectraMax Mini 多功能酶标仪
CloneSelect Imager FL 细胞生长分析系统
智能化共聚焦高内涵成像分析系统
MultiWash–C微孔板洗板机
芯片扫描仪GenePix 专业型4200 AL Molecular Devices
自动化细胞成像分析系统 ImageXpress Pico
多功能微孔板读板机 SpectraMax iD5
多功能酶标仪SpectraMax iD3
多功能酶标仪 SpectraMax i3x
ImageXpress Micro Confocal高内涵成像系统
微生物克隆筛选系统QPix 400
多功能酶标仪SpectraMax M5/M5e
高通量实时荧光检测分析系统 FLIPR Penta
卡盒式多功能微孔读板机 SpectraMax Paradigm
微孔板钙流检测工作站 FlexStation 3
关注
拨打电话
留言咨询