供货周期: | 一周 |
品牌: | |
规格: | 500 μg |
货号: | ANT-151 |
CAS号: |
Type | Mouse antibody Monoclonal. | ||||||
Introduction | Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. | ||||||
Clone | NYRHIV1gp120. | ||||||
Immunogen | r.gp120 (MN strain). | ||||||
Ig Subclass | mouse IgG1. | ||||||
Purification Method | Ion exchange column. | ||||||
Protein concentration | 1mg/ml in PBS (after reconstitution). | ||||||
Shipping Conditions | Antibody is shipped lyophilized at ambient temperature. | ||||||
Storage Procedures | In lyophilized form, for long periods, store at 4oC in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20oC. | ||||||
Reconstitution | Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. | ||||||
Titer | By direct ELISA (against recombinant gp120), 1:20,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories). | ||||||
Additional Information |
This is a binding and neutralizing antibody. Neutralization was tested in tissue culture. |
||||||
Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||||
Related Products |
|
相关产品
猴糜蛋白酶样弹性蛋白酶1(ELA1)ELISA kit
猴弹性蛋白酶2,中性粒细胞(ELA2)ELISA kit
牛脂多糖/内毒素(LPS) ELISA kit
大鼠细胞色素P450 2B1(Cyp2b1)ELISA kit
Dog Cytochrome P450 2B11(Cyp2b11) ELISA kit
Mouse Methylthioadenosine Phosphorylase(MTAP)ELISA kit
豚鼠胰淀粉酶α2A(AMY2A)ELISA Kit
猪胰岛素样生长因子1(IGF-1)ELISA Kit
人Klotho ELISA Kit
小鼠Klotho ELISA Kit
小鼠嗅觉标记蛋白(OMP)ELISA kit
人运甲状腺素蛋白/前白蛋白(TTR)ELISA kit
Human Placenta-specific gene 8 protein(PLAC8) ELISA kit
小鼠L氨基酸氧化酶(IL4I1)ELISA kit
植物过氧化氢酶2(CAT2/CAT)ELISA kit
详细地址
关注
拨打电话
留言咨询