英文名称 Anti-ADAMTS1
中文名称 整合素样金属蛋白酶与凝血酶1型抗体
别 名 A disintegrin and metalloproteinase with thrombospondin motifs 1; A disintegrin like and metalloprotease with thrombospondin type 1 motif 1; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 1; ADAM metallopeptidase with thrombospondin type 1 motif 1; ADAM TS 1; ADAM TS1; ADAMTS 1; ADAMTS; C3 C5; KIAA1346; METH 1; METH1.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 肿瘤 心血管 细胞生物 信号转导 细胞类型标志物 细胞骨架
蛋白分子量 predicted molecular weight: 106kDa
整合素样金属蛋白酶与凝血酶1型抗体性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from mouse ADAMTS1 C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素样金属蛋白酶与凝血酶1型抗体产品介绍 ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function.
Function : Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Subcellular Location : Secreted > extracellular space > extracellular matrix.
Post-translational modifications : The precursor is cleaved by a furin endopeptidase.
Similarity : Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 3 TSP type-1 domains.
抗体应在(-20℃)中冷冻干燥或浓缩的液体形式,直到需要,避免反复冷冻/解冻周期,降低抗体含量和浓度。相反,冻结在单次使用的等分试样重组抗体或添加防冻剂(甘油或乙二醇),从而使料液可以保持在-20℃下为液体形式,以使移液没有“解冻”。