接头蛋白DOK7抗体

参考价:¥1
供货周期: 一周
品牌: Abcam
规格: 0.2ml/200μg
货号:
CAS号:
上海基免实业有限公司
银牌会员4年生产商
关注展位 全部试剂
产品详情

接头蛋白DOK7抗体英文名称  Anti-DOK7 
中文名称  接头蛋白DOK7抗体 
别    名  Docking protein 7; DOK 7; DOK7; DOK7_HUMAN; Downstream of tyrosine kinase 7; Protein Dok-7. 
公司接头蛋白DOK7抗体应用于医学免疫学、动物免疫学、分子生物学、生物化学、临床医学、检验医学、动物医学、药学、理工、农学、环境学等生命科学密切相关的专业。   
浓    度  1mg/1ml 
规 格  0.1ml/100μg  0.2ml/200μg          
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse   
产品类型  一抗    
研究领域  细胞生物 神经生物学 信号转导 激酶和磷酸酶  
蛋白分子量  predicted molecular weight: 53kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human DOK7 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
(石蜡切片需做抗原修复) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
接头蛋白DOK7抗体产品介绍 The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) — recessively inherited disorders characterized by muscle weakness.
Function : Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Subcellular Location : Cell membrane. Cell junction > synapse. Accumulates at neuromuscular junctions.
Tissue Specificity : Preferentially expressed in skeletal muscle and heart Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).
DISEASE : Defects in DOK7 are the cause of familial limb-girdle myasthenia autosomal recessive (LGM) [MIM:254300]; also called congenital myasthenic syndrome type 1B or CMS1B. LGM is a congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
Similarity : Contains 1 IRS-type PTB domain.
Contains 1 PH domain.
Database links : 
【存储要求】连续使用时4°C存储,保质期六个月;接头蛋白DOK7抗体期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。
实验的用途:
1)WB:Western Blotting 免疫印迹
2)IH:Immunohistochemistry 免疫组化
3)IH(P):Immunohistochemistry Parraffin sections 免疫组化(石蜡)
4)IH(F):Immunohistochemistry Frozen sections 免疫组化(冰冻)
5)IC:Immunocytochemistry 免疫细胞化学

相关产品

同类推荐 更多
接头蛋白DOK7抗体由上海基免实业有限公司为您提供,货号,规格:0.2ml/200μg ,CAS号:,如您想了解更多关于接头蛋白DOK7抗体价格、接头蛋白DOK7抗体结构式、批发、用途等信息,欢迎咨询。除供应接头蛋白DOK7抗体外,还可为您提供其他等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,上海基免客户服务电话,售前、售后均可联系。
Business information
工商信息 信息已认证
contact us
联系方式

详细地址

上海市金山工业区亭卫公路6558号9幢2441室
当前位置: 上海基免 试剂 接头蛋白DOK7抗体

关注

拨打电话

留言咨询