α内磺肽抗体

英文名称  Anti-ENSA/ARPP-19 

中文名称  α内磺肽抗体 

α内磺肽抗体别    名  Alpha endosulfine; ARPP 19e; Endosulfine alpha; ENSA_HUMAN. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Cow, Horse, Rabbit

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、α内磺肽抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  神经生物学 生长因子和激素 通道蛋白 细胞膜受体  

蛋白分子量  predicted molecular weight: 13kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human ENSA/ARPP-19 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Sulfonylureas are a class of drugs commonly used in the management of noninsulin-dependent diabetes mellitus. ENSA/ARPP-19, also known as ARPP-19e, is a 121 amino acid protein that localizes to the cytoplasm and belongs to the endosulfine family. ENSA/ARPP-19 is an endogenous regulator of the β-cell K(ATP) channels and reduces K(ATP) channel currents by inhibiting sulfonylurea from binding to the receptor thereby stimulating insulin secretion by pancreatic β cells. It is suggested that ENSA/ARPP-19 expression is decreased in brains of both Alzheimer's disease (AD) and Down's syndrome patients. Widely expressed with high levels in skeletal muscle and brain and lower levels in pancreas, ENSA/ARPP-19 is phosphorylated by PKA and exists as eight alternatively spliced isoforms. ENSA/ARPP-19 is encoded by a gene located on human chromosome 1q21.3.

Function : ENSA (Alpha endosulfine) is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. The recombinant protein inhibits binding of labeled glibenclamide to beta cell membranes. It also inhibits cloned K(ATP) channel currents and thereby stimulates insulin secretion. It was proposed that endosulfine is an endogenous regulator of the K(ATP) channel, which has a key role in the control of insulin release and, more generally, couples cell metabolism to electrical activity.

Subunit : Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.

Subcellular Location : Cytoplasmic

Tissue Specificity : Widely expressed with high levels in skeletal muscle and brain α内磺肽抗体and lower levels in the pancreas.

Post-translational modifications : Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.

Similarity : Belongs to the endosulfine family.

Database links : UniProtKB/Swiss-Prot: O43768.1

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGF(Mouse Nerve growth factor) ELISA kit  小鼠神经生长因子

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGF(Human Nerve growth factor) ELISA kit  人的神经生长因子

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGF ELISA Kit  大鼠神经生长因子

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGF- Beta(Human Nerve growth factor- Beta) ELISA kit  人的神经生长因子-β

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGB(Rat Neuroglobin,NGB) ELISA Kit  大鼠脑红蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGB(Mouse Neuroglobin) ELISA Kit  小鼠脑红蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGAL(Mouse neutrophil gelatinase-associated lipocalin) ELISA Kit  小鼠中性粒细胞明胶酶相关脂质运载蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGAL(Human neutrophil gelatinase-associated lipocalin) ELISA Kit  人中性粒细胞明胶酶相关脂质运载蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NGAL ELISA Kit  大鼠中性粒细胞明胶酶相关脂质运载蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NFKB p65 (Human NF-κΒ p65) KLISA Kit  人细胞核因子/k基因结合核因子

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NF-KapB p65(Mouse nuclear factor-KapB p65) ELISA Kit  小鼠核因子κB亚基p65亲和肽

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NF-KapB p65 ELISA Kit  大鼠核因子κB亚基p65亲和肽

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NF-KapB p65 (Rabbit nuclear factor-KapB p65) ELISA Kit  兔核因子κB亚基p65亲和肽

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NF(Human neurofilament protein) ELISA Kit  人神经丝蛋白

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NE-B(Human Noradrenaline Bitartas) ELISA Kit  人重酒石酸去甲肾上腺素

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NE(Mouse neutrophil elastase) ELISA Kit  小鼠中性粒细胞弹性蛋白酶

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NE(Human neutrophil elastase) ELISA Kit  人中性粒细胞弹性蛋白酶

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NE ELISA Kit  大鼠中性粒细胞弹性蛋白酶

α内磺肽抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NE (Rabbit neutrophil elastase) ELISA Kit  兔子中性粒细胞弹性蛋白酶

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 n-DNA-Ab(Human natural deoxyribonucleic acid antibody) ELISA Kit  人抗天然脱氧核糖核酸抗体

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2 NCAM-L1/CD171(Human Neural cell adhesion molecule ligand 1) ELISA Kit  人神经细胞粘附分子配体1

更多α内磺肽抗体价格、 α内磺肽抗体批发价、 α内磺肽抗体品牌、厂家及抗体详细说明书，都可跟我们销售人员索取。