供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg 0.2ml/200μg |
货号: | |
CAS号: |
英文名称 Anti-EphA1/Ephrina1/Ephrin A1
中文名称 内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)
内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)别 名 Ephrin-A1; EPH-related receptor tyrosine kinase ligand 1; LERK-1; Immediate early response protein B61; Tumor necrosis factor alpha-induced protein 4; TNF alpha-induced protein 4; Ephrin-A1, secreted form; EFNA1_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体,产品货期短、内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)品质保证、全国免邮,并提供抗体相应实验技术指导。
研究领域 肿瘤 心血管 神经生物学 激酶和磷酸酶 细胞表面分子
蛋白分子量 predicted molecular weight: 19/22kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Ephrin A1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4) not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Function : Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Subunit : Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.
Ephrin-A1, secreted form: Secreted.
Tissue Specificity : Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Post-translational modifications : Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Similarity : Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Database links : UniProtKB/Swiss-Prot: Q9Y258.1
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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更多内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)价格、 内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)批发价、 内皮细胞受体蛋白酪氨酸激酶A抗体(肿瘤坏死因子α诱导蛋白4)品牌、厂家及抗体详细说明书,都可跟我们销售人员索取。
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