G1氨基丁酸A型受体α1抗体|0.1ml/100μg 0.2ml/200μg |-上海研生实业有限公司

产品详情

英文名称 Anti-GABRA1/GABA A Receptor alpha 1

中文名称 G1氨基丁酸A型受体α1抗体

G1氨基丁酸A型受体α1抗体别名 ECA4; EJM; EJM5; Gaba receptor alpha 1 polypeptide; GABA(A) receptor; GABA(A) receptor subunit alpha 1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABRA 1; GABRA1; Gamma aminobutyric acid (GABA) A receptor alpha 1; Gamma aminobutyric acid A receptor alpha 1; Gamma aminobutyric acid receptor subunit alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1; GBRA1_HUMAN.

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse

产品类型一抗

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研究领域免疫学神经生物学信号转导激酶和磷酸酶

蛋白分子量 predicted molecular weight: 52kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human GABRA1

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].

Function : Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.

Subcellular Location : Secreted and Cell membrane.

Tissue Specificity : Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Similarity : Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Contains 2 Sushi (CCP/SCR) domains.

GABA是中枢神经系统主要的抑制性神经递质，而GABA-ARα1是GABA的受体之一,在脑内分布最普遍,α1亚单位与其功能密切相关。通过位于脑内的GABA受体发挥抑制性作用GABA及GABA-ARα1在癫痫、颅脑损伤、神经毒剂中毒等疾病、损伤和中毒模型中的表达、结合都有改变。

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

G1氨基丁酸A型受体α1抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

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供货周期：	现货
品牌：	GenWay
规格：	0.1ml/100μg 0.2ml/200μg
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