生长抑制DNA损伤基因34抗体|0.1ml/100μg 0.2ml/200μg |-上海研生实业有限公司

产品详情

英文名称 Anti-GADD34

中文名称 生长抑制DNA损伤基因34抗体

生长抑制DNA损伤基因34抗体别名 Growth arrest and DNA damage-inducible 34; Apoptosis associated protein; GADD 34; Growth arrest and DNA damage inducible 34; Growth arrest and DNA-damage-inducible 34; PPP1R15A; Protein phosphatase 1 regulatory (inhibitor) subunit 15A; Protein phosphatase 1 regulatory subunit 15A.

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat

产品类型一抗

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、生长抑制DNA损伤基因34抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域细胞生物免疫学信号转导细胞凋亡细胞周期蛋白激酶和磷酸酶表观遗传学

蛋白分子量 predicted molecular weight: 75(hu); 72(mo); 64(rat)kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human GADD34 (560-572aa)

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with 生长抑制DNA损伤基因34抗体apoptosis following ionizing radiation.

Function : Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.

Subunit : Interacts with PCNA (By similarity). Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.

Subcellular Location : Endoplasmic reticulum.

Post-translational modifications : Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity.

Similarity : Belongs to the PPP1R15 family.

Database links : UniProtKB/Swiss-Prot: O75807.1

GADD34蛋白与细胞凋亡和死亡密切相关，在某种程度上决定了细胞周期的进程。

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

生长抑制DNA损伤基因34抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2

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供货周期：	现货
品牌：	GenWay
规格：	0.1ml/100μg 0.2ml/200μg
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