供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg 0.2ml/200μg |
货号: | |
CAS号: |
英文名称 Anti-Supervillin
中文名称 监理蛋白抗体
监理蛋白抗体别 名 Archvillin; p205/p250; SVIL_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体,产品货期短、监理蛋白抗体品质保证、全国免邮,并提供抗体相应实验技术指导。
研究领域 细胞生物 信号转导 表观遗传学
蛋白分子量 predicted molecular weight: 248kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Supervillin
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
监理蛋白抗体产品介绍 Supervillin is an F-actin-binding protein originally with two reported isoforms of 205/250 kDa. The longer isoform, named archvillin, is muscle-specific. Supervillin is a tightly bound peripheral membrane protein that is concentrated at sites of epithelial cell-cell adhesion. It contributes to cell-cell adhesion, motility regulation, and information transfer between cell compartments. The COOH-terminus of supervillin is homologous to villin/gelsolin but is not responsible for the tight binding to the actin cytoskeleton in vivo. The NH2-terminus contains functional nuclear localization sequences and F-actin and myosin II binding domains. It has been suggested that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains. Supervillin has been identified as a transcriptional activator of the androgen receptor. Supervillin is found in many cells of several species, but is most abundant in muscle, bone marrow, thyroid gland, and salivary gland.
Function : Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).
Subunit : Associates with F-actin. Interacts with NEB. Interacts with MYH9. Interacts with MYLK. Isoform 2 interacts with TRIP6. Isoform 2 interacts with DYNLT1 (By similarity).
Anti-NF-KappaB p105 细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格: 0.1ml
监理蛋白抗体Anti-Phospho-NF-KappaB p105 (Ser927) 磷酸化细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格: 0.1ml
Anti-Phospho-NF-KappaB p105 (Ser933) 磷酸化细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格: 0.1ml
Anti-NGFR/p75NTR 神经生长因子受体抗体 Multi-class antibodies 规格: 0.1ml
Anti-NGF-beta 神经生长因子-β抗体 Multi-class antibodies 规格: 0.1ml
Anti-NGN3 神经元素3抗体 Multi-class antibodies 规格: 0.2ml
Anti-NGX6 鼻咽癌细胞相关基因6抗体 Multi-class antibodies 规格: 0.1ml
Anti-NHE1 钠氢通道蛋白抗体 Multi-class antibodies 规格: 0.2ml
Anti-NIK/MAPKKK14 NFkB诱导激酶抗体 Multi-class antibodies 规格: 0.2ml
Anti-NIS 钠碘转运体蛋白抗体 Multi-class antibodies 规格: 0.2ml
Anti-NIT2 NIT2蛋白抗体 Multi-class antibodies 规格: 0.2ml
Anti-Substance P Receptor P物质受体抗体 Multi-class antibodies 规格: 0.1ml
Anti-NK-2R 神经激肽A受体/K物质受体抗体 Multi-class antibodies 规格: 0.1ml
Anti-NKA 神经激肽A抗体 Multi-class antibodies 规格: 0.2ml
Anti-NKB 神经激肽B抗体 Multi-class antibodies 规格: 0.2ml
Anti-NKG2A NK细胞受体2A抗体 Multi-class antibodies 规格: 0.2ml
Anti-NKG2C NK细胞受体2C抗体 Multi-class antibodies 规格: 0.2ml
Anti-NKG2D/CD314 NK细胞受体2D抗体 Multi-class antibodies 规格: 0.2ml
更多监理蛋白抗体价格、监理蛋白抗体批发价、监理蛋白抗体品牌、厂家及抗体详细说明书,都可跟我们销售人员索取.
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