供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg |
货号: | |
CAS号: |
英文名称 Anti-Phospho-SHIP1 (Tyr1020)
中文名称 磷酸化SH2结构含磷酸肌醇SHIP1抗体
磷酸化SH2结构含磷酸肌醇SHIP1抗体别 名 P-SHIP1 (Tyr1020); Inositol polyphosphate 5 phosphatase of 145kDa; 4; 5-trisphosphate 5-phosphatase 1; hp51CN; hSHIP; Inositol polyphosphate 5 phosphatase 145kDa; Inositol polyphosphate 5 phosphatase; Inositol polyphosphate 5 phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; INPP 5D; INPP5D; INPP5D protein; MGC104855; MGC142140; MGC142142; p150 ship; p150Ship; Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1; Phosphatidylinositol-3; SH2 containing inositol 5 phosphatase; SH2 containing inositol phosphatase isoform b; SH2 domain containing inositol 5' phosphatase 1; SH2 domain containing inositol phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5''-phosphatase 1; SHIP 1; SHIP-1; SHIP1; SHIP1_RAT; Signaling inositol polyphosphate 5 phosphatase SIP 145; Signaling inositol polyphosphate 5 phosphatase SIP145; SIP 145; SIP-145; SIP145.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow
产品类型 一抗 磷酸化抗体
公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体,产品货期短、磷酸化SH2结构含磷酸肌醇SHIP1抗体品质保证、全国免邮,并提供抗体相应实验技术指导。
研究领域 免疫学 信号转导 激酶和磷酸酶 t-淋巴细胞
蛋白分子量 predicted molecular weight: 134kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from rat SHIP1 around the phosphorylation site of Tyr1020
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
磷酸化SH2结构含磷酸肌醇SHIP1抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.
Function : Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity).
磷酸化SH2结构含磷酸肌醇SHIP1抗体固生蛋白抗体 Anti-Tenascin 1ml
骨形态发生蛋白-7抗体 Anti-BMP-7 0.2ml
骨形态发生蛋白4抗体 Anti-BMP4 0.1ml
骨形态发生蛋白-2抗体 Anti-BMP2 0.1ml
骨桥蛋白抗体 Anti-OPN 0.1ml
骨成型蛋白受体1A抗体 Anti-BMPR-1A 0.1ml
骨保护蛋白配体抗体 Anti-OPGL/RANKL 0.1ml
骨保护蛋白/护骨素抗体 Anti-OPG 0.1ml
骨保护蛋白/骨钙素抗体 Anti-BGP 0.1ml
谷氨酸脱羧酶-67抗体 Anti-GAD-67 0.1ml
谷氨酸脱羧酶-65抗体 Anti-GAD-65 0.1ml
谷氨酸受体2D抗体 Anti-NR2D/NMDAR2D 0.2ml
谷氨酸受体2C抗体 Anti-NR2C/NMDAR2C 0.2ml
谷氨酸受体2B抗体 Anti-NR2B/NMDAR2B 0.1ml
谷氨酸受体2A抗体 Anti-NR2A/NMDAR2A 0.1ml
谷氨酸受体1抗体 Anti-NR1/NMDAR1 0.1ml
更多磷酸化SH2结构含磷酸肌醇SHIP1抗体价格、磷酸化SH2结构含磷酸肌醇SHIP1抗体批发价、磷酸化SH2结构含磷酸肌醇SHIP1抗体品牌、厂家及抗体详细说明书,都可跟我们销售人员索取.
相关产品
炭疽热毒素受体2(ANTXR2)酶联免疫分析试剂盒
碳分解代谢物阻遏4样蛋白(CCRN4L)酶联免疫分析试剂盒
碳酸酐酶Ⅰ(CA1)酶联免疫分析试剂盒
碳酸酐酶Ⅱ(CA2)酶联免疫分析试剂盒
碳酸酐酶Ⅲ(CA3)酶联免疫分析试剂盒
碳酸酐酶Ⅳ(CA4)酶联免疫分析试剂盒
碳酸酐酶ⅤB(CA5B)酶联免疫分析试剂盒
碳酸酐酶Ⅵ(CA6)酶联免疫分析试剂盒
碳酸酐酶Ⅸ(CA9)酶联免疫分析试剂盒
碳酸酐酶Ⅻ(CA12)酶联免疫分析试剂盒
羰基还原酶1(CBR1)酶联免疫分析试剂盒
羰基还原酶3(CBR3)酶联免疫分析试剂盒
羰基还原酶4(CBR4)酶联免疫分析试剂盒
糖蛋白Ⅴ(GP5)酶联免疫分析试剂盒
糖蛋白A33(GPA33)酶联免疫分析试剂盒
详细地址
关注
拨打电话
留言咨询