癌症干细胞系列产品

癌症干细胞(Cancer Stem Cell,CSC),又称癌干细胞、肿瘤干细胞,是指具有干细胞(Stem cell)性质的癌细胞,也就是具有“自我复制”(self-renewal)以及“具有多细胞分化”(differentiation)等能力。通常这类的细胞被认为有形成肿瘤,发展成癌症的潜力,特别是随着癌症转移出去后,产生新型癌症的来源。在功能实验中被定义为当移植进免疫缺陷小鼠体内时能形成肿瘤和自我更新的细胞。

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产品引用文献:

[CD34 Antibody NB600-1071) Fiorina P, Pietramaggiori G, Scherer SS, et al. The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplant. 2010;19(11):1369- 81. [PMID: 20977829]
[CD34 Antibody NB600-1071] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9.
[CD44 Antibody AP00142PU-N] Walker F, Zhang H-H, Odorizzi A, Burgess AW. LGR5 Is a Negative Regulator of Tumorigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines. PLoS ONE. 201. [PMID 21829496]
[EpCAM Antibody NB110-56958] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9.
[EpCAM Antibody NB110-56958] Ralhan R, Cao J, Lim T, et al, EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis ,BMC Cancer 10 (2010) 331
[EpCAM Antibody NB110-56958] Maetzel D, Denzel S, Mack B, et al, Nuclear signalling by tumor-associated antigen EpCAM ,Nature Cell Biology11 (2009) 162-171. (IP)
[p75 NGF Receptor Antibody M-009-100] Wiese S, Herrmann T, Drepper C, Jablonka S, Funk N, Klausmeyer A, Rogers ML, Rush RA & Sendtner M (2009) Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos. Nat Protoc. 2010;5(1):31-8
[p75 NGF Receptor Antibody M-006-100 and NGF Receptor Antibody NB100-1539] Davies A. et al (2010) The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins,

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