R-钙粘附分子抗体

本公司是最专业R-钙粘附分子抗体供应商，提供R-钙粘附分子抗体的报价，泛素样蛋白Sumo2/3抗体咨询，

英文名称  Anti-R-cadherin/Cadherin 4

中文名称  R-钙粘附分子抗体

别    名  Cadherin 4; Cadherin4; Cadherin-4 CDH4; R CAD; Retinal Cadherin.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg

R-钙粘附分子抗体概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Horse

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学 激酶和磷酸酶 细胞粘附分子 糖蛋白  

蛋白分子量  predicted molecular weight: 81kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human R-cadherin(423-475aa)

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Cadherins constitute a superfamily of calcium-dependent intercellular adhesion molecules and are thought to play a role in cell recognition and segregation, morphogenetic regulation, and tumor suppression. R Cadherin is expressed mainly in the brain but is also found in other tissues.

Function : Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Subcellular Location : Cell membrane; Single-pass type I membrane protein.

Tissue Specificity : Expressed mainly in brain but also found in other tissues.

Similarity : Contains 5 cadherin domains.

R-钙粘附分子抗体R-钙粘附分子,是依赖钙离子的细胞间糖蛋白粘附分子的一种，主要是参与细胞间同源性粘附、调控和介导细胞间相互反应，在肿瘤的迁移、分化中起到一定的作用。在脑组织中表达外，其他组织中已有定位。