供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
本公司是最专业视网膜母细胞瘤结合蛋白5抗体供应商,提供视网膜母细胞瘤结合蛋白5抗体的报价,泛素样蛋白Sumo2/3抗体咨询,
英文名称 Anti-RBBP5
中文名称 视网膜母细胞瘤结合蛋白5抗体
别 名 RBBP 5; RBQ 3; RBQ3; Retinoblastoma binding protein 5; Retinoblastoma binding protein RBQ3; Retinoblastoma binding protein5; SWD1; SWD1, Set1c WD40 repeat protein, homolog.
浓 度 1mg/1ml
规 格 0.2ml/200μg
视网膜母细胞瘤结合蛋白5抗体概述:
B淋巴细胞在抗原的刺激下,能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的,不可能持续分化增殖下去,因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞,再进一步克隆化,这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力,又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit
产品类型 一抗
研究领域 肿瘤 免疫学 染色质和核信号
蛋白分子量 predicted molecular weight: 59kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RBBP5
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 RbBP5, retinoblastoma binding protein 5, belongs to a highly conserved subfamily of WD proteins and contains 6 WD repeats. It binds preferentially to underphosphorylated retinoblastoma protein, which is involved in the control of cell proliferation. RbBP5 is a component of the SET1 complex and of MLL containing complexes. RbBP5 is phosphorylated in response to DNA damage, probably by ATM/ATR.
Function : As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Subunit : Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL, MLL2/ALR, MLL3 and MLL4/WBP7), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A.
Subcellular Location : Nucleus.
视网膜母细胞瘤结合蛋白5抗体Tissue Specificity : Ubiquitously expressed.
Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity : Contains 6 WD repeats.
相关产品
大鼠转化生长因子β刺激蛋白22(TSC22)检测试剂盒
大鼠转甲状腺素蛋白(TTR)检测试剂盒
Hs 181.Tes(正常人睾丸细胞)
Hs 1.Tes(正常人睾丸细胞)
Hs 683(人脑视神经胶质瘤细胞)
GC-2spd(ts)(小鼠精母细胞)
Ca Ski(人小肠颈部表皮样癌细胞)
Beta-TC-6(小鼠胰腺癌beta细胞)
HIT-T15(仓鼠beta胰岛细胞)
hFOB 1.19(人SV40转染成骨细胞)
PT67(小鼠逆转录病毒包装细胞)
THLE-3(人肝上皮细胞)
7F2(小鼠杂交瘤细胞)
SW 900 [SW-900; SW900](人肺癌细胞)
NCI-H1869 [H1869](人肺癌细胞)
详细地址
关注
拨打电话
留言咨询