供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
我公司专业供应RAB3-GTP酶激活蛋白催化亚单位2抗体。了解更多关于的RAB3-GTP酶激活蛋白催化亚单位2抗体英文名称,RAB3-GTP酶激活蛋白催化亚单位2抗体产品别名规格请看以下说明书。
英文名称 Anti-RAB3GAP2
中文名称 RAB3-GTP酶激活蛋白催化亚单位2抗体
别 名 DKFZp434D245; FLJ14579; KIAA0839; p150; Rab3 GAP p150; Rab3 GAP regulatory subunit; Rab3 GAP150; Rab3 GTPase activating protein 150 kDa subunit; Rab3 GTPase activating protein non catalytic subunit; RAB3 GTPase activating protein subunit 2 (non catalytic); RAB3 GTPase activating protein subunit 2; RAB3GAP150; RGAP iso; RP11 568G11.1; RBGPR_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
RAB3-GTP酶激活蛋白催化亚单位2抗体的功能:
抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep
产品类型 一抗
研究领域 细胞生物 发育生物学 神经生物学 信号转导 G蛋白信号
蛋白分子量 predicted molecular weight: 156kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RAB3GAP2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 ab 3 GAP p150 is a ubiquitously expressed protein that contains 1,393 amino acids and belongs to the Rab3-GAP regulatory subunit family. Defects in Rab 3 GAP p150 are the cause of Martsolf and Warburg Micro syndrome. Both syndromes are characterized by congenital cataracts, microphthalmia, postnatal microcephaly and developmental delay, and are inherited in an autosomal recessive manner. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and Rab 3 GAP p150 that interacts with DMXL2. Existing as two alternatively spliced isoforms, the Rab 3 GAP p150 gene is conserved in chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana and rice. The Rab 3 GAP p150 gene contains 36 exons and maps to human chromosome 1q41.
Function : RAB3GAP2 is a regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. It is required for normal eye and brain development and may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Subunit : The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2
Subcellular Location : Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
Tissue Specificity : Ubiquitous.
DISEASE : efects in RAB3GAP2 are the cause of Martsolf syndrome (MARTS) [MIM:212720]. Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive.
Defects in RAB3GAP2 are the cause of Warburg micro syndrome type 2 (WARBM2) [MIM:614225]. WARBM2 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.
RAB3-GTP酶激活蛋白催化亚单位2抗体Similarity : Belongs to the Rab3-GAP regulatory subunit family.
Database links : UniProtKB/Swiss-Prot: Q9H2M9.1
相关产品
大鼠转化生长因子β刺激蛋白22(TSC22)检测试剂盒
大鼠转甲状腺素蛋白(TTR)检测试剂盒
Hs 181.Tes(正常人睾丸细胞)
Hs 1.Tes(正常人睾丸细胞)
Hs 683(人脑视神经胶质瘤细胞)
GC-2spd(ts)(小鼠精母细胞)
Ca Ski(人小肠颈部表皮样癌细胞)
Beta-TC-6(小鼠胰腺癌beta细胞)
HIT-T15(仓鼠beta胰岛细胞)
hFOB 1.19(人SV40转染成骨细胞)
PT67(小鼠逆转录病毒包装细胞)
THLE-3(人肝上皮细胞)
7F2(小鼠杂交瘤细胞)
SW 900 [SW-900; SW900](人肺癌细胞)
NCI-H1869 [H1869](人肺癌细胞)
详细地址
关注
拨打电话
留言咨询