供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
我公司专业供应RAM-11抗体。了解更多关于的RAM-11抗体英文名称,RAM-11抗体产品别名规格请看以下说明书。
英文名称 Anti-Rab27a
中文名称 RAM-11抗体
别 名 RAB27A; GS2; HsT18676; MGC117246; RAB27; RAM; Rab27a; 2210402C08Rik; 2410003M20Rik; 4933437C11Rik; ash; RB27A_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
RAM-11抗体的功能:
抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 转录调节因子 合成与降解 转运蛋白
蛋白分子量 predicted molecular weight: 25kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RAM-11 C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Summary: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].
Function : Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Subunit : Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5 (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D.
Subcellular Location : Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
Tissue Specificity : Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
DISEASE : Griscelli syndrome 2 (GS2) [MIM:607624]: Rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.
RAM-11抗体Similarity : Belongs to the small GTPase superfamily. Rab family.
Database links : UniProtKB/Swiss-Prot: P51159.3
相关产品
大鼠转化生长因子β刺激蛋白22(TSC22)检测试剂盒
大鼠转甲状腺素蛋白(TTR)检测试剂盒
Hs 181.Tes(正常人睾丸细胞)
Hs 1.Tes(正常人睾丸细胞)
Hs 683(人脑视神经胶质瘤细胞)
GC-2spd(ts)(小鼠精母细胞)
Ca Ski(人小肠颈部表皮样癌细胞)
Beta-TC-6(小鼠胰腺癌beta细胞)
HIT-T15(仓鼠beta胰岛细胞)
hFOB 1.19(人SV40转染成骨细胞)
PT67(小鼠逆转录病毒包装细胞)
THLE-3(人肝上皮细胞)
7F2(小鼠杂交瘤细胞)
SW 900 [SW-900; SW900](人肺癌细胞)
NCI-H1869 [H1869](人肺癌细胞)
详细地址
关注
拨打电话
留言咨询