肿瘤血管内皮调节蛋白Robo4抗体

本公司是最专业肿瘤血管内皮调节蛋白Robo4抗体供应商，提供肿瘤血管内皮调节蛋白Robo4抗体的报价，肿瘤血管内皮调节蛋白Robo4抗体咨询，技术服务，欢迎来电咨询选购。

英文名称  Anti-Robo4

中文名称  肿瘤血管内皮调节蛋白Robo4抗体

别    名  Magic roundabout; MRB; Robo 4; Roundabout homolog 4; Roundabout homolog 4 magic roundabout; Roundabout homolog 4 Precursor.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg

肿瘤血管内皮调节蛋白Robo4抗体概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型  一抗    

研究领域  肿瘤 心血管 细胞生物 免疫学 神经生物学  

蛋白分子量  predicted molecular weight: 108kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Robo4 (301-340aa)

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Robo4 is a vascular specific receptor that is a repulsive cue to migrating endothelial cells during vascular development. Guidance and patterning of axons are orchestrated by cell surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Robo4 is specifically expressed in the vascular endothelium during murine embryonic development; the only Robo family member expressed in primary endothelial cells. Robo4 also has a role in regulating the migration of endothelial cells during tumor angiogenesis.

Function : Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit protein.

Subunit : Interacts with SLIT2 and ENAH.

Tissue Specificity : Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.

Similarity : Belongs to the immunoglobulin superfamily. ROBO family.

Contains 2 fibronectin type-III domains.

肿瘤血管内皮调节蛋白Robo4抗体Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Database links : UniProtKB/Swiss-Prot: Q8WZ75.1

Gene ID: 54538(human)