肌动蛋白调节蛋白CAPG抗体

我公司专业供应肌动蛋白调节蛋白CAPG抗体。了解更多关于的肌动蛋白调节蛋白CAPG抗体英文名称肌动蛋白调节蛋白CAPG抗体产品别名规格请看以下说明书。

英文名称  Anti-Actin Regulatory Protein CAPG

中文名称  肌动蛋白调节蛋白CAPG抗体

别    名  Actin capping protein GCAP39; Actin regulatory protein CAP G; Actin regulatory protein CAP-G; AFCP; CAPG; CAPG_HUMAN; Capping protein (actin filament) gelsolin like; Capping protein gelsolin like; gCap39; Gelsolin like capping protein; Macrophage capping protein; Macrophage-capping protein; mbh1; MCP; Myc basic motif homolog 1.

浓    度  1mg/1ml

规 格  0.2ml/200μg

肌动蛋白调节蛋白CAPG抗体的功能：

抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Cow, Horse, Sheep  

产品类型  一抗    

研究领域  细胞生物 免疫学 信号转导  

蛋白分子量  predicted molecular weight: 38kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Actin Regulatory Protein CAPG

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Caldesmon, Filamin 1, Nebulin, Plastin, ADF, Gelsolin, CapG, Dematin and Cofilin are differentially expressed Actin-binding proteins. Both muscular (CDh) and non-muscular (CD1) forms of Caldesmon bind to Actin as well as to Calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CD1 is widely expressed in non-muscle tissues and cells. CapG, also designated Actin-regulatory protein and macrophage-capping protein, is a macrophage-specific protein that reversibly blocks the barbed ends of Actin filaments, but does not sever preformed ones. The interactions of CapG with Actin may be important in the regulation of nuclear and cytoplasmic structures. CapG is a calcium-sensitive DNA-binding protein that plays a role in macrophage function. It is expressed in macrophages and macrophage-like cells and can localize both to the nucleus and the cytoplasm.

Function : Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Subcellular Location : Cytoplasm. Nucleus. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity : Macrophages and macrophage-like cells.

Post-translational modifications : The N-terminus is blocked.

Similarity : Belongs to the villin/gelsolin family.

肌动蛋白调节蛋白CAPG抗体Contains 3 gelsolin-like repeats.

Database links : UniProtKB/Swiss-Prot: P40121.2