供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
本公司是最专业钙粘蛋白相关的神经受体2抗体供应商,提供钙粘蛋白相关的神经受体2抗体的报价,钙粘蛋白相关的神经受体2抗体咨询,技术服务,欢迎来电咨询选购。
英文名称 Anti-CNR2/CB2
中文名称 钙粘蛋白相关的神经受体2抗体
别 名 Cannabinoid receptor 2; Cannabinoid Receptor II; Cannabinoid receptor 2 macrophage; CB 2; CB-2; CB2; CNR2; CNRII; CNR-2; CNR 2; CX 5; CX5.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
钙粘蛋白相关的神经受体2抗体概述:
B淋巴细胞在抗原的刺激下,能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的,不可能持续分化增殖下去,因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞,再进一步克隆化,这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力,又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
研究领域 细胞生物 免疫学 神经生物学 细胞膜受体
蛋白分子量 predicted molecular weight: 40kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human CNR2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects(including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq].
Function : Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Subcellular Location : Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Tissue Specificity : Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
Post-translational modifications : Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
钙粘蛋白相关的神经受体2抗体Similarity : Belongs to the G-protein coupled receptor 1 family.
大麻素受体2(大麻素II型受体)CB2受体在正常皮肤主要分布于上皮细胞、巨噬细胞、肥大细胞、感觉神经纤维、毛囊、汗腺等部位, 参与皮肤感觉传导、疼痛机制、皮肤免疫、皮肤肿瘤、细胞分化等重要的生理病理过程.
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