供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
我公司供应质优价美的科研产品,阿片样物质结合蛋白/细胞粘附分子样蛋白抗体产品质量保证,提供阿片样物质结合蛋白/细胞粘附分子样蛋白抗体技术支持,有任何质量问题可免费包退包换,欢迎来电咨询!我们将竭诚为您服务!
英文名称 Anti-OPCML
中文名称 阿片样物质结合蛋白/细胞粘附分子样蛋白抗体
别 名 opioid binding protein/cell adhesion molecule-like; OPCML; OBCAM; OPCM; 3732419F12; C230027C17; 2900075O15RIK; AI844366; B930023M13RIK; Gm181; IGLON1; MGC99974; OPCM_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit
产品类型 一抗
研究领域 肿瘤 免疫学 细胞粘附分子
蛋白分子量 predicted molecular weight: 35kDa
性 状 Lyophilized or Liquid
少突细胞髓磷脂糖蛋白抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
免 疫 原 KLH conjugated synthetic peptide derived from human OPCML N-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Function : Binds opioids in the presence of acidic lipids; probably involved in cell contact.
Subcellular Location : Cell membrane.
DISEASE : Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Similarity : Belongs to the immunoglobulin superfamily. IgLON family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
阿片样物质结合蛋白/细胞粘附分子样蛋白抗体Database links : UniProtKB/Swiss-Prot: Q14982.1
OPCML基因的作用是产生一种能帮助卵巢表面分子粘合在一起的蛋白质,当这一基因关闭后,细胞间的粘合力减弱,此时如细胞加速生长,即有可能产生早期癌变。
经研究发现,OPCML能够增加细胞的黏附能力,抑制癌细胞的增殖,OPCML可能是一个新的抑癌基因.在早期病症中能抑制癌变细胞蛋白质的生成,并有效阻止癌变细胞的生长。
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