膜转运蛋白XK抗体

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英文名称  Anti-XKR1

中文名称  膜转运蛋白XK抗体

别    名  XK; Kell complex 37 kDa component; Membrane transport protein XK; XK related protein 1; XKR1; XRG1.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Chicken

产品类型  一抗    

研究领域  心血管 细胞生物 转运蛋白  

蛋白分子量  predicted molecular weight: 49kDa

性    状  Lyophilized or Liquid

膜转运蛋白XK抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

免 疫 原  KLH conjugated synthetic peptide derived from human XKR1

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 XK is the Kell blood group 'precursor substance'. This protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. The Kell blood group is constituted by two covalently linked antigens at the surface of red blood cells, Kell and KX. Whereas Kell is a metalloprotease with demonstrated in vitro enzymatic activity, the role of KX thereon, and/or alone, remains unknown, although its absence is linked to the McLeod syndrome, a neuroacanthocytosis. KX appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface.

Function : May be involved in sodium-dependent transport of neutral amino acids or oligopeptides

Subunit : Heterodimer with Kell; disulfide-linked.

Subcellular Location : Membrane; Multi-pass membrane protein (Potential).

Tissue Specificity : High levels in skeletal muscle, heart, brain,

膜转运蛋白XK抗体DISEASE : Defects in XK are the cause of McLeod syndrome (MLS) [MIM:300842]. It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.

Similarity : Belongs to the XK family.