神经丛蛋白A4抗体

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英文名称  Anti-Plexin A4     

中文名称  神经丛蛋白A4抗体     

别    名  FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; PLXNA4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003.  

浓    度  1mg/1ml     

规 格  0.2ml/200μg    

抗体来源  Rabbit      

克隆类型  polyclonal     

交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep    

产品类型  一抗        

研究领域  发育生物学 神经生物学      

蛋白分子量  predicted molecular weight: 210kDa     

性    状  Lyophilized or Liquid     

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免 疫 原  KLH conjugated synthetic peptide derived from human Plexin A4

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Forms a receptor complex with neuropilin-1 and can propagate semaphorin-3A elicited inhibitory signals into cells and neurons.

Function : Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

Subunit : Interacts with NRP1 and NRP2

Subcellular Location : Cell membrane; Single-pass type I membrane protein

Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity : Belongs to the plexin family.

Contains 4 IPT/TIG domains.

神经丛蛋白A4抗体 Contains 3 PSI domains.

Contains 1 Sema domain.

Database links : UniProtKB/Swiss-Prot: Q9HCM2.4