供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
我公司是国内最权威的抗体代理商,细胞膜调控蛋白Paralemmin 1抗体价格优惠,细胞膜调控蛋白Paralemmin 1抗体质量保证,欢迎来电订购或咨询在线客服!
英文名称 Anti-Paralemmin 1
中文名称 细胞膜调控蛋白Paralemmin 1抗体
别 名 KIAA0270; PALM; PALM_HUMAN; Paralemmin; Paralemmin1;Paralemmin-1.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep
产品类型 一抗
研究领域 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号 细胞膜蛋白
蛋白分子量 predicted molecular weight: 42kDa
性 状 Lyophilized or Liquid
细胞膜调控蛋白Paralemmin 1抗体着国内抗体行业的崛起,我国自主品牌的抗体,都蛮多了,质量也不错,技术在逐渐成熟,价格也比国外的廉价的多,受到国内顾客的热捧,我们公司为了方便客户,特推出阴离子转运蛋白-1抗体规格15ug、30ug、50ug、100ug,15ug和30ug等,我们全国包邮,大中城市免费快递。抗体分子是生物学和医学领域用途最为广泛的蛋白分子。抗体作为疾病预防、诊断和治疗的制剂已有上百年的发展历史。随着生命科学研究的迅猛发展,抗体工程在生物技术领域越来越占有非常重要的地位。我公司可为您提供快速的、高质量的和经济的多克隆抗体制备服务,并将成为您在科研及生产中的得力助手。
免 疫 原 KLH conjugated synthetic peptide derived from human Paralemmin 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events.
Function : Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
Subunit : Interacts with dopamine receptor DRD3.
Subcellular Location : Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Basolateral cell membrane; Lipid-anchor (By similarity). Apicolateral cell membrane; Lipid-anchor (By similarity). Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
细胞膜调控蛋白Paralemmin 1抗体Tissue Specificity : Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.
Similarity : Belongs to the paralemmin family.
Database links : UniProtKB/Swiss-Prot: O75781.2
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