供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg和0.2ml/200μg等规格 |
货号: | |
CAS号: |
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英文名称 Anti-PSCDBP/CYTIP
中文名称 胞粘蛋白结合调节蛋白抗体
别 名 B31; CASP; Cbp HE; CYBR; CYTHIP; Cytip; CYTIP_HUMAN; Cytohesin binder and regulator; Cytohesin-associated scaffolding protein; Cytohesin-binding protein HE; Cytohesin-interacting protein; HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein; Pleckstrin homology Sec7 and coiled-coil domains-binding protein.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
产品类型 一抗
研究领域 神经生物学 信号转导 转录调节因子 细胞粘附分子 表观遗传学
蛋白分子量 predicted molecular weight: 40kDa
性 状 Lyophilized or Liquid
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免 疫 原 KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.
Function : By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
Subunit : Interacts with CYTH1 and SNX27.
Subcellular Location : Cytoplasm. Early endosome. Recruited from the cytosol to endosomes by SNX27.
胞粘蛋白结合调节蛋白抗体Tissue Specificity : Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow.
Similarity : Contains 1 PDZ (DHR) domain.
Database links : UniProtKB/Swiss-Prot: O60759.2
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