原钙粘附蛋白11Y抗体

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英文名称  Anti-PCDH11Y

中文名称  原钙粘附蛋白11Y抗体

别    名  PCDH 11; PCDH 11X; PCDH 11Y; PCDH 22; PCDH PC; PCDH Y; PCDH11; PCDH11X; PCDH22; PCDHY; Protocadherin 11; Protocadherin 11 X linked; Protocadherin 11 Y linked; Protocadherin 22; Protocadherin on the Y chromosome; Protocadherin PC; Protocadherin prostate cancer; Protocadherin Y; Protocadherin11; Protocadherin22; ProtocadherinY; PC11Y_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep

产品类型  一抗    

研究领域  肿瘤 神经生物学 细胞粘附分子 细胞骨架 细胞膜蛋白  

蛋白分子量  predicted molecular weight: 144kDa

性    状  Lyophilized or Liquid

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免 疫 原  KLH conjugated synthetic peptide derived from human PCDH11Y

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Protocadherins (PCDHs) are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH11X (protocadherin 11 X-linked), a 1,347 amino acid protein, and PCDH11Y (protocadherin 11 Y-linked), a 1,340 amino acid protein, are single-pass type I membrane proteins that each contain seven cadherin domains and each exist as multiple alternatively spliced isoforms. Expressed strongly in both adult and fetal brain tissue, PCDH11X and PCDH11Y function as calcium-dependent cell adhesion proteins that are essential for the segmental development and function of the central nervous system. Variations in the PCDH11X and PCDH11Y genes are associated with an increased susceptibility to brain-related afflictions, such as late-onset Alzheimer's disease.

Function : PCDH11Y (Protocadherin 11 Y-linked) is a member of the protocadherin family. Protocadherins constitute the largest subgroup within the cadherin family of calcium-dependent cell-cell adhesion molecules. Their specific functions are unknown but they may be involved in the establishment and function of specific neuronal connections in the brain. The PCDH11Y gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome (PCDH11X).

Subunit : Interacts with CTNNB1.

Subcellular Location : Cell membrane; Single-pass type I membrane protein.

Tissue Specificity : Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.

DISEASE : Note=A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.

原钙粘附蛋白11Y抗体Similarity : Contains 7 cadherin domains.

Database links : UniProtKB/Swiss-Prot: Q9BZA8.1