供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0032 |
CAS号: | 详见产品说明书 |
转录因子AP2α+β抗体
〖别名〗Activating enhancer binding protein 2 alpha; Activating enhancer binding protein 2 beta; AP2TF; TFAP2; TFAP2A; TFAP2B; Transcription factor AP2 alpha; Transcription factor AP2 beta; AP2A_HUMAN; AP2B_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep
〖产品类型〗转录因子AP2α+β抗体一抗
〖研究领域〗肿瘤 发育生物学 转录调节因子 结合蛋白 细胞分化 表观遗传学
〖蛋白分子量〗predicted molecular weight: 48kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human AP2 alpha + beta
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer. AP2 alpha is the only AP2 protein required for early morphogenesis of the lens vesicle. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Function : Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Subunit : Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A-transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2.
Subcellular Location : Nuclear.
Post-translational modifications : Sumoylated on Lys-10; which inhibits transcriptional activity (Probable).
DISEASE : Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major features include cutaneous anomalies, ocular anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair) anomalies.
Similarity : Belongs to the AP-2 family.
Database links : UniProtKB/Swiss-Prot: P05549.1 UniProtKB/Swiss-Prot: Q92481.2
本公司产品现货供应,货期短,质量可靠。仅用于科研实验不应用于临床。我们用专业的态度,一流的服务,全程实验指导,让你的数据不在成为实验奇谈。选择优质的转录因子AP2α+β抗体,你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种。让你的科研之路不再布满荆棘。
我们还可以为客户提供产品说明书。转录因子AP2α+β抗体拥有高纯度、高效价、高特异性的特点,可以应用于多种实验。免费送货上门,为您大大节省了时间和金钱。
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Ab-(001)-01645 Anti-CCR-8 细胞表面趋化因子受体8抗体 ,英文名: Anti-CCR-8 ,规格: 0.2ml
Ab-(001)-01646 Anti-CCL25/CCR-9 细胞表面趋化因子受体9抗体 ,英文名: Anti-CCL25/CCR-9 ,规格: 0.2ml
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Ab-(001)-01648 Anti-CCR-10 细胞表面趋化因子受体10抗体 ,英文名: Anti-CCR-10 ,规格: 0.2ml
Ab-(001)-01649 Anti-CCRK 细胞周期相关激酶抗体 ,英文名: Anti-CCRK ,规格: 0.2ml
Ab-(001)-01650 Anti-CD10/CALLA CD10抗体 ,英文名: Anti-CD10/CALLA ,规格: 0.2ml
Ab-(001)-01651 Anti-CD105/Endoglin CD105抗体 ,英文名: Anti-CD105/Endoglin ,规格: 0.1ml
Ab-(001)-01652 Anti-CD117/c-kit/SCFR 干细胞生长因子受体/细胞表面分化抗原抗体 ,英文名: Anti-CD117/c-kit/SCFR ,规格: 0.1ml
Ab-(001)-01653 Anti-phospho-c-kit (Tyr936) 磷酸化原癌基因c-kit抗体 ,英文名: Anti-phospho-c-kit ,规格: 0.1ml
Ab-(001)-01654 Anti-Phospho-c-Kit (Tyr703) 磷酸化原癌基因c-kit抗体 ,英文名: Anti-Phospho-c-Kit ,规格: 0.1ml
Ab-(001)-01655 Anti-Phospho-c-Kit (Tyr719) 磷酸化原癌基因c-kit抗体 ,英文名: Anti-Phospho-c-Kit ,规格: 0.1ml
Ab-(001)-01656 Anti-CD133 antigen 造血干细胞抗原CD133抗体 ,英文名: Anti-CD133 ,规格: 0.1ml
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Ab-(001)-01659 Anti-CD146/MCAM 黑色素瘤细胞粘附分子CD146抗体 ,英文名: Anti-CD146/MCAM ,规格: 0.2ml
Ab-(001)-01660 Anti-CD141/THBD 凝血调节蛋白抗体 ,英文名: Anti-CD141/THBD ,规格: 0.1ml
Ab-(001)-01661 Anti-CD13/ANPEN CD13氨肽酶N抗体 ,英文名: Anti-CD13/ANPEN ,规格: 0.1ml
Ab-(001)-01662 Anti-CD14 内毒素受体抗体 ,英文名: Anti-CD14 ,规格: 0.1ml
Ab-(001)-01663 Anti-CD27/TNFRSF7 CD27抗体 ,英文名: Anti-CD27/TNFRSF7 ,规格: 0.2ml
Ab-(001)-01664 Anti-CD28 CD28抗体 ,英文名: Anti-CD28 ,规格: 0.1ml
Ab-(001)-01665 Anti-CD144/VECD 上皮型钙粘附分子抗体 ,英文名: Anti-CD144/VECD ,规格: 0.1ml
Ab-(001)-01666 Anti-CD147/TCSF 细胞外基质金属蛋白酶诱导因子抗体 ,英文名: Anti-CD147/TCSF ,规格: 0.1ml
Ab-(001)-01667 Anti-CD160/By55 NK细胞受体BY55抗体 ,英文名: Anti-CD160/By55 ,规格: 0.2ml
Ab-(001)-01668 Anti-CD161/NK1.1 CD161抗体 ,英文名: Anti-CD161/NK1.1 ,规格: 0.2ml
Ab-(001)-01669 Anti-CD163/M130 CD163抗体 ,英文名: Anti-CD163/M130 ,规格: 0.2ml
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Ab-(001)-01676 Anti-CD158e NK细胞抑制性受体3DL1抗体 ,英文名: Anti-CD158e ,规格: 0.2ml
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