供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg /0.2ml/200μg |
货号: | TE-KT-0035 |
CAS号: | 详见产品说明书 |
细胞周期后期促进蛋白亚基10抗体
〖别名〗ANAPC 10; anapc10; Anaphase promoting complex 10; Anaphase promoting complex subunit 10; Anaphase-promoting complex subunit 10; Apc 10; APC10; APC10_HUMAN; Cyclosome subunit 10; DKFZP564L0562; Doc 1; Doc1; OTTHUMP00000220297; OTTHUMP00000220298; OTTHUMP00000220299; OTTHUMP00000220300; OTTHUMP00000220303.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗细胞周期后期促进蛋白亚基10抗体polyclonal
〖交叉反应〗Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep
〖产品类型〗一抗
〖研究领域〗细胞生物 细胞周期蛋白 泛素
〖蛋白分子量〗predicted molecular weight: 21kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human APC10
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.
Function : Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Subunit : The APC/C is composed of at least 12 subunits. The C-terminus of APC10 binds to CDC27/APC3.
Similarity : Belongs to the APC10 family.
Contains 1 DOC domain.
Database links : UniProtKB/Swiss-Prot: Q9UM13.1
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我们还可以为客户提供产品说明书。细胞周期后期促进蛋白亚基10抗体拥有高纯度、高效价、高特异性的特点,可以应用于多种实验。免费送货上门,为您大大节省了时间和金钱。
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Ab-(001)-01794 Anti-CDK1/Cdc2 周期素依赖性激酶1抗体 ,英文名: Anti-CDK1/Cdc2 ,规格: 0.1ml
Ab-(001)-01795 Anti-CDK2 周期素依赖性激酶2抗体 ,英文名: Anti-CDK2 ,规格: 0.1ml
Ab-(001)-01796 Anti-Phospho-CDK2 (Thr160) 磷酸化周期素依赖性激酶2抗体 ,英文名: Anti-Phospho-CDK2 ,规格: 0.1ml
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Ab-(001)-01798 Anti-CDK4 周期素依赖性激酶4抗体 ,英文名: Anti-CDK4 ,规格: 0.1ml
Ab-(001)-01799 Anti-CDK5 周期素依赖性激酶5抗体 ,英文名: Anti-CDK5 ,规格: 0.2ml
Ab-(001)-01800 Anti-CDK6 周期素依赖性激酶6抗体 ,英文名: Anti-CDK6 ,规格: 0.2ml
Ab-(001)-01801 Anti-CDK7 周期素依赖性激酶7抗体 ,英文名: Anti-CDK7 ,规格: 0.2ml
Ab-(001)-01802 Anti-CDK8 周期素依赖性激酶8抗体 ,英文名: Anti-CDK8 ,规格: 0.2ml
Ab-(001)-01803 Anti-CDK9 周期素依赖性激酶9抗体 ,英文名: Anti-CDK9 ,规格: 0.2ml
Ab-(001)-01804 Anti-Phospho-CDK9 (Thr186) 磷酸化周期素依赖性激酶9抗体 ,英文名: Anti-Phospho-CDK9 ,规格: 0.1ml
Ab-(001)-01805 Anti-CDKN1C/p57 Kip2 周期蛋白依赖激酶抑制因子1C抗体 ,英文名: Anti-CDKN1C/p57 ,规格: 0.2ml
Ab-(001)-01806 Anti-Phospho-p57 Kip2 (Thr310) 磷酸化周期蛋白依赖激酶抑制因子1C抗体 ,英文名: Anti-Phospho-p57 ,规格: 0.1ml
Ab-(001)-01807 Anti-CGP-39/YKL-40 软骨糖蛋白39抗体 ,英文名: Anti-CGP-39/YKL-40 ,规格: 0.1ml
Ab-(001)-01808 Anti-CEA 癌胚抗原抗体 ,英文名: Anti-CEA ,规格: 0.1ml
Ab-(001)-01809 Anti-CEA 癌胚抗原抗体 ,英文名: Anti-CEA ,规格: 0.1ml
Ab-(001)-01810 Anti-CEA 癌胚抗原单克隆抗体(包被) ,英文名: Anti-CEA ,规格: 0.1ml
Ab-(001)-01811 Anti-CEA 癌胚抗原单克隆抗体(检测) ,英文名: Anti-CEA ,规格: 0.1ml
Ab-(001)-01812 Anti-CEAcam8/CD67 癌胚抗原相关细胞粘附分子8抗体 ,英文名: Anti-CEAcam8/CD67 ,规格: 0.2ml
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Ab-(001)-01815 Anti-Phospho-CEBP alpha (Ser21) 磷酸化转录调节因子CEBP α 抗体 ,英文名: Anti-Phospho-CEBP ,规格: 0.1ml
Ab-(001)-01816 Anti-Phospho-CEBP alpha (Thr222/226) 磷酸化转录调节因子CEBP α 抗体 ,英文名: Anti-Phospho-CEBP ,规格: 0.1ml
Ab-(001)-01817 Anti-CEBP Beta 转录调节因子C/EBP β抗体 ,英文名: Anti-CEBP ,规格: 0.1ml
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Ab-(001)-01819 Anti-Phospho-CEBP beta (Thr235) 磷酸化转录调节因子CEBP β抗体 ,英文名: Anti-Phospho-CEBP ,规格: 0.1ml
Ab-(001)-01820 Anti-CENPA 着丝粒蛋白A ,英文名: Anti-CENPA ,规格: 0.2ml
Ab-(001)-01821 Anti-Phospho-CENP-A (Ser7) 磷酸化着丝粒蛋白A ,英文名: Anti-Phospho-CENP-A ,规格: 0.1ml
Ab-(001)-01822 Anti-Cecropin 抗菌肽/天蚕素抗体 ,英文名: Anti-Cecropin ,规格: 0.2ml
Ab-(001)-01823 Anti-Cecropin 杀菌肽/天蚕抗菌肽抗体 ,英文名: Anti-Cecropin ,规格: 0.2ml
Ab-(001)-01824 Anti-HER2/C-erbB-2 HER2抗体 ,英文名: Anti-HER2/C-erbB-2 ,规格: 0.1ml
Ab-(001)-01825 Anti-HER4/ErbB4 HER4抗体 ,英文名: Anti-HER4/ErbB4 ,规格: 0.2ml
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Ab-(001)-01827 Anti-Phospho-HER4 (Tyr1284) 磷酸化HER4抗体 ,英文名: Anti-Phospho-HER4 ,规格: 0.1ml
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Ab-(001)-01830 Anti-Phospho-c-Fos (Thr232) 磷酸化c-fos抗体 ,英文名: Anti-Phospho-c-Fos ,规格: 0.1ml
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